When dry curing, proving you only add the quantities of salt, sugar and cure from the calculator you can be certain of the maximum resulting cure PPM and %age of salt. There is never 100% take up and from lab testing I have found that. When I have used the calculator in the past (aiming for a 175 ppm nitrite) the lab tests have come back showing an actual residual level of ~100 ppm. This is fine and well within what I would expect.
With wet brining though there is a lot of confusion as to the cure levels that need to be used. This is down to the vague wording used in both the US and EU regulations and is now measured not input cure and not in final ppm. In the US the USDA Inspectors Calculation Handbook also appears to interchange the cure calculations for pump bringing and immersion brining. When I have had samples of immersion cured bacon lab tested I found that in order to get a resulting level of Nitrite to be comparable with the 100-175 ppm residual Nitrite, i needed to create an equilibrium strength cure. When using the cure strength based upon one of the immersion calculators the end result was actually cure and salt levels that were 10x too high. Because of this I would recommend that the cure calculators not be used for immersion brining and that the immersion cure be calculated to be the same strength as the required resulting ppm.